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apalutamide will lower the extent or outcome of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medicines which are CYP2C19 substrates can lead to lessen exposure to these remedies.diazepam improves amounts of lomitapide by affecting hepatic/inte